Position racks in center and lower third of oven. Place roasting pan on lower rack: fill halfway with water. Preheat oven to 325F. Grease 9"x3" springform pan. In food processor, pulse cookies and 2 Tbsp. sugar until ground. Stir in butter. Press into pan.
On medium-high speed, beat cream cheese and remaining sugar until fluffy, 3-4 minutes. Beat in eggs, one at a time, then cream, flour and vanilla. Pour into pan.
Bake on center rack 1 hour 15 minutes, or until center jiggles slightly. Turn off oven. Let stand in oven with door closed 1 hour. Run knife around edge of pan. Cool on rack. Chill overnight. Remove side of pan.